Name: 1,7-dimethylxanthine powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

1,7-Dimethylxanthine, also called paraxanthine, is the main active ingredient of caffeine. Dimethylxanthine is also the main metabolite of caffeine. Dimethylxanthine is more effective than caffeine. Fewer side effects and better absorption.

Product Name

1,7-dimethylxanthine

Appearance

White powder

Specification

98%

CAS No

611-59-6

Molecular Formula

C7H8N4O2

Package

1kg ziplock bag + aluminum foil bag or 25kg cardboard drum

GET A QUOTE

Add to Quote List 목록 찾아보기

Desciption

Product information
What is dimethylxanthine Powder?
Before we understand 1,7-dimethylxanthine we need to look at caffeine, which we know is the most widely used central nervous system stimulant in the world. It is used to overcome fatigue, improve cognitive function, increase energy and even athletic performance, including aerobic and anaerobic performance, muscle strength, power and endurance. It also increases metabolic rate and reduces pain perception, which is key to maximizing human performance.
Biochemically, caffeine is a methylxanthine, and although caffeine has many
benefits, but their positive effects vary widely. The effectiveness of caffeine supplements may be affected by dose, form, timing of intake, training status and even an individual’s genetic ability to metabolize caffeine! In fact, less than half of people who consume caffeine metabolize it well Caffeine and get all the positive benefits. For people who are slow metabolizers of caffeine, consuming caffeine may result in little to no energy and may even lead to anxiety, insomnia, gastrointestinal discomfort, headaches, and increased heart rate. Science is beginning to show that there are huge differences in how different people metabolize caffeine
Different, and it all depends on your ability to convert caffeine into paraxanthine, the main active ingredient responsible for caffeine's positive benefits. Paraxanthine is the most desirable of the three metabolites. As an adenosine antagonist, its effect is similar to caffeine, but it is more effective, less toxic, and has fewer side effects than caffeine itself. This is the 1,7-dimethylxanthine we recommend. Paraxanthine is a natural plant compound found in the stamens of coffee, cocoa fruit, ivy, and citrus flowers. It is also the main metabolite of caffeine. In vivo, caffeine is demethylated to dimethylxanthine in the liver by the cytochrome P450 enzyme system, specifically the CYP1A2 isoenzyme.
Joyous 1,7-dimethylxanthine powder specification

Terms	Standard	Terms	Standard
Product Name	1,7-dimethylxanthine	Appearance	White Powder
Purity	98%	Loss on Drying	≤8%
Total Heavy Metals	≤10 ppm	Ash	≤1%
As	≤0.5ppm	Total Plate Count	≤1000 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

What is the role of 1,7-dimethylxanthine?
Chemically, paraxanthine is 1,7-dimethylxanthine, with two methyl groups at positions 1 and 7. Caffeine needs to go through the process of "absorption → metabolic decomposition" when entering the body. Caffeine is mainly decomposed into three metabolites: theophylline, paraxanthine and theobromine. Paraxanthine accounts for about 80% of the caffeine consumed, of which the largest A small proportion of caffeine is metabolized to theobromine and theophylline. l1J Research shows that 11% of caffeine is ultimately converted into theobromine and 4% into theophylline. The largest component is paraxanthine (84%).

Compared with theobromine, theophylline, and caffeine, paraxanthine has the shortest half-life and the greatest plasma clearance. Paraxanthine has a half-life of 3.1 hours, while caffeine has a half-life of 4.1 hours, which is significantly different from theophylline's 6.2 hours and theobromine's 7.2 hours. The total plasma clearance of paraxanthine (2.20 mL/min/kg) is greater than caffeine (2.07 mL/min/kg), and significantly greater than theobromine (1.20 mL/min/kg) and theophylline (0.93 in/kg ).

In addition, paraxanthine is less toxic than caffeine and is the least harmful of caffeine-derived metabolites. Paraxanthine is also less anxiety-producing (causing anxiety palpitations) than caffeine. Paraxanthine, unlike other caffeine metabolites, can cause nausea, diarrhea, tachycardia, and arrhythmias.
Paraxanthine has been tested in multiple toxicology studies to evaluate mutagenicity, genotoxicity, and acute and repeated dose oral toxicity in rats, but no toxic effects were reported.
Safety profile of paraxanthine
Toxicological studies determined the LD 50 (dose of a substance that causes death in 50% of test animals) of paraxanthine to be 1601 mg/kg body weight. The LD 50 of 5J caffeine is much lower at 192 mg/kg, indicating that caffeine is significantly more toxic than paraxanthine alone. Additionally, the caffeine metabolites theobromine and theophylline have LD50s of 1,265 mg/kg and 25 mg/kg, respectively. These findings suggest that caffeine may be more toxic because its metabolite is not paraxanthine, further supporting paraxanthine as a means of achieving the CNS stimulating effects of caffeine without producing the effects that may be attributed to Side effects of other caffeine metabolites.
The metabolism of caffeine may affect the amount of paraxanthine available. The ratio of paraxanthine to caffeine in plasma can determine whether a person's metabolism is "fast" or "slow," and thus whether paraxanthine levels are high or low. There is evidence that genetic polymorphisms influence an individual's response to and metabolism of caffeine. Caffeine is a potent adenosine receptor antagonist: caffeine blocks the effects of adenosine in the central nervous system. Single nucleotide polymorphisms in the gene encoding the adenosine A2A receptor. (SNP) has been used to classify individuals as having high or low caffeine sensitivity.
Mechanism of action of paraxanthine
Like caffeine, paraxanthine is a central nervous system stimulant that induces motor activation through its ability to block adenosine receptors. However, paraxanthine appears to have higher binding potency to adenosine Al and A2a receptors. In fact, paraxanthine has a stronger motor-activating effect than caffeine, theobromine, and theophylline. The difference in the motor-activating effects of paraxanthine and caffeine is related to differences in their ability to inhibit cGMP (cyclic guanosine monophosphateª), preferentially inhibiting phosphodiesterase (PDE). Paraxanthine, but not caffeine, has been shown to induce a significant increase in striatal cGMP concentrations. [14J The results strongly suggest an interaction between the two major mechanisms (A1 receptor antagonism and PDE inhibition) responsible for the locomotor-activating effects of paraxanthine, which increase neurotransmitters through enhanced nitric oxide signaling Release of glutamate and dopamine. Additionally, paraxanthine enhances neurotransmission by enhancing nitric oxide (NO) neurotransmitter signaling. PDE9 terminates NO neurotransmission by metabolizing cGMP back to GMP.
Caffeine and paraxanthine: central nervous system effects
Paraxanthine has been shown to have the same effects on the central nervous system as caffeine. In one study, subjects received 2 or 4 mg per kilogram of caffeine or paraxanthine or a placebo three days after abstaining from methylxanthines. Both caffeine and paraxanthine significantly increase diastolic blood pressure, plasma epinephrine levels, and free fatty acids, indicating their potent and fat-burning abilities. Caffeine and paraxanthine produced responses of similar magnitude at 4 mg/kg; however, caffeine at 2 mg/kg appeared to produce a greater response than paraxanthine. Therefore, caffeine and paraxanthine have similar sympathomimetic effects.
How to use 1,7-dimethylxanthine
Paraxanthine has been tested in clinical trials for its ability to increase cognitive flexibility, sustain attention, improve working memory and inhibitory control. In a clinical trial, acute ingestion of paraxanthine was observed to improve cognition and short-term memory and help maintain attention.
The trial used a randomized, double-blind, placebo-controlled, crossover and counterbalanced approach and included 12 healthy male and female subjects (24±5 years, 170.0±12 cm, 72.9±19 kg, 24.8±4 kg/m2) , were randomly assigned to take placebo (PL) or 200 mg of paraxanthine. Participants completed a stimulant sensitivity and side effect questionnaire and then performed a battery of standard cognitive function tests, including the Berg Card Sorting Task Test (BCST), a test of executive functions that assesses long-term thinking, including reasoning, learning , executive control and attention shifting; the Go/No Go test (GNG), which assesses sustained attention and response control by reaction time and accuracy to visual stimuli; in another double-blind, placebo-controlled, crossover and balanced In the trial, 13 well-trained runners (27.1±5 years, 68.6±9 kg, 22.2±2.7kg/m2, 15.7±5% fat, 53.7±11 mL/kg/min peak VO2) were randomly assigned to take 400 mg placebo (PL), 200 mg PL + 200 mg caffeine (CA), 200 mg PL + 200 mg paraxanthine (PX), or 200 mg CA + 200 mg caffeine (CA). PX(CA+PX), with a 7-day washout period between treatments. Each participant had a fasting blood sample collected and completed a pre-supplementation side effect questionnaire as well as a BCST and PVTT. Participants then rested for 60 min, repeated the test, ran 10 km on the treadmill (48.4 ± 6.7 min), and then performed a set of post-exercise tests. BCST outcome analysis data showed that paraxanthine increased correct responses and decreased errors, while caffeine increased errors. After exercise, the total error increased in all groups except the paraxanthine group, indicating fatigue. Paraxanthine significantly improved errors, reducing them by 10.6%, while caffeine increased them by 23.3%. The paraxanthine group also had faster post-exercise reaction times than the placebo group. Additionally, paraxanthine also showed faster reaction times in pre-exercise testing (compared to placebo) and post-exercise testing (compared to caffeine). Results from this clinical trial suggest that acute paraxanthine supplementation (independent of caffeine) improves cognition and reduces fatigue before and after exercise. The trial also showed that adding caffeine to paraxanthine did not provide any additional benefits. Paraxanthine Increases Muscle Mass, Strength, and Endurance Paraxanthine supplementation was evaluated on muscle mass after 28 days compared with other common ingredients commonly used in sports supplements, including L-theanine, alpha-GPC, and taurine , impact on strength and endurance performance. Five groups of male Swiss albino mice were orally administered paraxanthine (20.5 mg/kg/day, human equivalent dose [HED] 100 mg), L-theanine (10.28 mg/kg/day, HED 50 mg), α- GPC (41.09 mg/kg/day, HED 200 mg), taurine (102.75 mg/kg/day, HED 500 mg), or control (carboxymethylcellulose) for four weeks.
Athletic performance was assessed using forelimb grip strength and treadmill endurance exercise. All animals received treadmill training for 60 minutes, 5 days per week. Blood is drawn to analyze blood lipids, liver health, kidney function and nitric oxide levels. Compared with the control group, paraxanthine significantly increased forelimb grip strength by 17%, treadmill performance by 39%, gastrocnemius and soleus muscle mass by 14% and 41% respectively, and nitric oxide levels by 100%, while reducing triglycerides. esters, total cholesterol and low-density lipoprotein, HDL increased compared to control as well as L-theanine, α-GPC and taurine. The results of this preliminary study indicate that paraxanthine is an active ingredient in improving exercise performance compared to control, L-theanine, alpha-GPC, and taurine. Formulated with paraxanthine, which has been shown to be more effective, safer, less toxic and has fewer side effects than caffeine. Paraxanthines are less bitter than not only caffeine but also other methylxanthines at the same dose. Additionally, paraxanthine requires the same dosage as caffeine (100 to 300 mg per serving) to easily replace existing energy, pre-workout, or cognitive function formulas. A paraxanthine supplement product that is HPLC tested for purity, patented, and GRAS filed. Paraxanthine has been formulated as pre-workout, fat loss, and nootropic supplements, including MuscleTech’s Burn iQ and EuphoriQ, and Explabs’ Energy Gummies.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides 1,7-dimethylxanthine powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules, sachets, and pellets with low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy 1,7-dimethylxanthine powder?
We offer the best 1,7-dimethylxanthine powder at the most competitive price.1,7-dimethylxanthine Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide 1,7-dimethylxanthine powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, and we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

REQUEST MORE DETAILS

Please fill out the form below and click the button to request more information about

We provide high-quality products and services, as well as customized pellets. We are a professional ingredient supplier and solution provider.

Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

Follow Us

Lates News: Don't miss our news subscription, please fill in the form below.

Leave Message

FirstName*

LastName*

Email*

Tel No.

Message

우리는 귀하의 온라인 경험을 개선하기 위해 Cookie를 사용합니다. 이 웹사이트를 계속 검색하면 귀하가 Cookie 사용에 동의하는 것으로 간주됩니다.