Name: Citicoline powder,Citicoline Sodium
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Citicoline is generally circulated in the market as a common drug. It is a brain metabolism activator. It can promote brain cell respiration, improve brain function, enhance the function of the ascending reticular structure activation system, promote awakening, and reduce cerebrovascular resistance.

Product Name

Citicoline

Specification

99%

Appearance

white powder

Type

Nucleoside Derivatives

CAS No

987-78-0

Other names

CDP-choline

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Desciption

Product information
Overview of Citicoline
Citicoline is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. exert neuroprotective effect. Generally, citicoline exists in the form of sodium salt. Its English aliases include cytidinediphosphocholine, CDP-choline, etc. As a common supplement that has been circulated in the market for a long time, citicoline can be extracted from liver or yeast, or Can be synthesized chemically. The synthesis method involves the reaction of cytosine-5'-diphosphate and ethyleneimine to generate cytosine-5'-diphosphate aminoethyl ester, which is then methylated with methyl iodide. It can also be obtained by direct condensation of cytosine-5'-phosphate amide and phosphocholine ester. There are three upstream products of citicoline, glucose syrup, choline chloride, and orotic acid. That is, the synthesis route can be glucose syrup + choline chloride + orotic acid = citicoline.
Joyous Citicoline powder specification

Terms	Standard	Terms	Standard
Product Name	Citicoline	Appearance	white powder
Assay	99%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Some Benefits of Citicoline
1. Effect of Citicoline on Consciousness Disorder and Post-stroke Hemiplegia
(1) Improve the brain waves of patients with consciousness disorders, rats whose brains are in anaerobic or hypoxic conditions, and dogs with thalamic infarction.
(2) It can inhibit the increase in cortical brain wave awakening response and muscle evoked potential threshold caused by stimulation of the cerebral cortex, and can also promote the effects of the ascending reticular activating system and pyramidal system, thereby improving the level of consciousness and motor function. (domestic rabbit).
(3) It can inhibit stroke-prone rats under experimental cerebral ischemia, cerebral ischemia-reperfusion rats, ischemic rats under hypoxic conditions and experimental cerebral infarction monkeys. The onset of acute stroke and neurological symptoms (disorder of consciousness, movement disorders) and reduced mortality.
(4) It can increase cerebral blood flow and reduce cerebral vascular resistance in patients with cerebral circulation disorders, thereby improving cerebral circulation. In particular, it can increase blood flow in the brainstem (dogs).
(5) For patients with cerebrovascular disorders, it can be seen on electromyography that it can increase the reduced maximum work capacity of paralyzed muscles, prolong the time when fatigue occurs under heavy load, and improve central motor dysfunction.
(6) It can promote the uptake of glucose in the brain (cerebral ischemia-reperfusion rats, cat brain perfusion method), inhibit the accumulation of lactic acid in the brain (cat brain perfusion method), and improve the brain mitochondria of rabbits with experimental cerebral infarction. Decreased respiratory function, promoted the biosynthesis of glucose to acetylcholine that was reduced due to cerebral ischemia, improved the metabolic turnover of dopamine (rats), inhibited the release of fatty acids in the brain during cerebral ischemia (rats), etc., indicating that this product has improved The role of brain function and brain metabolism.
(7) For rats with cerebral ischemia, it can be absorbed into the nerve cell membrane, promote the biosynthesis of phospholipids and improve phospholipid metabolism.
2. The role of citicoline in pancreatitis
(1) It can reduce the degeneration of dogs and rats with experimental acute pancreatitis, mainly necrosis of pancreatic and liver tissue, and prolong the survival period. In addition, when this product is used together with a proteolytic inhibitor (beside mesylate or aprotinin), the effect is stronger than when used alone.
(2) From the fact that this product is easily absorbed in the membrane lipid part of the pancreas during the recovery period of experimental acute pancreatitis rats, it can be inferred that this product participates in the biological membrane repair of the pancreas through the biosynthesis of lecithin. .
(3) It can inhibit the lecithinase activity in human pancreatic juice and serum of patients with acute pancreatitis, and inhibit the decomposition of lecithin (in vitro experiments).
Safety Data for Citicoline
in vitro studies
To determine the potential neuroprotective activity of citicoline and Homotaurine, treated retinal cells were treated with increasing concentrations of Citicoline or Homotaurine for 24 hours. Citicoline or Homotaurine at 1 μM, 10 μM, and 100 μM was used to investigate whether it might cause reduced cell viability in retinal cells. In cultures treated with Citicoline or Homotaurine, retinal cells were well preserved with no evidence of toxicity or significantly reduced survival after treatment. 100 μM citicoline is harmless to retinal glial cells in vitro, and 100 μM Homotaurine is an effective concentration to enhance neuroprotection in experimental glaucoma models. Therefore, this concentration of citicoline and homomotaurine was used in all subsequent experiments. To evaluate whether co-treatment with citicoline and Homotaurine can induce synergistic neuroprotection against glutamate excitotoxicity, retinal cell cultures were exposed to 100 μM citicoline 24 h before glutamate treatment. 100 μM Homotaurine and 100 μM Citicoline + Homotaurine. In the presence of 100 μM citicoline, a significant increase in cell viability was observed [1].
in vivo studies
Administration of citicoline at a dose of 1000 mg/kg produced a more pronounced clonic seizure threshold and tonic phase of seizures with lethal outcome (18.54 and 50.08%, respectively, compared to controls). The anticonvulsant effect is most obvious after injecting citicoline at a dose of 1000 mg/kg [2].
Cellular Assays The assay used to assess cell viability in retinal cells is the MTT reduction assay. To evaluate the effects of citicoline and Homotaurine on cell survival, cells were subdivided into three groups and treated with 1 μM, 10 μM and 100 μM of Citicoline and 1 μM, 10 μM and 100 μM of Homotaurine for 24 h. To evaluate the neuroprotective effects of citicoline and Homotaurine, 100 μM Citicoline, 100 μM Homotaurine or 100 μM Citicoline + Homotaurine were administered 24 h before glutamate treatment and 30 min before high glucose (HG) treatment. Process cells. Add MTT to the wells at a final concentration of 0.5 mg/mL and keep at 37 °C for 1 h. After this time, the medium was removed and the reduced MTT (blue formazan product) was dissolved by adding 100 μL DMSO to each well. After stirring the plate for 15 minutes, measure the optical density of the dissolved formazan product in each well using an automated microplate reader with a test wavelength of 570 nm and a reference wavelength of 690 nm [1].
Animal experiment
Mice[1] Experiments were performed on male C57Bl/6 mice (n = 69) weighing 23-27 g. The study was conducted in two series. In series I, the dose-dependent effect of citicoline on epileptic seizure threshold in mice was evaluated. Measurements were taken 1 hour after administration of citicoline. Citicoline was injected intraperitoneally at doses of 500 and 1000 mg/kg (0.04 mL per 20 g of body weight). Control animals received an equal volume of saline under similar conditions. In series II, the duration of citicoline effects was estimated at 3 and 6 hours after a single intraperitoneal injection of citicoline.
references
[1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.
[2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7

Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Citicoline powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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Where to buy Citicoline powder?
We offer the best Citicoline powder at the most competitive price.Citicoline Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide Citicoline powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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