Name: liposomal glutathione,Liposomal Glutathione Liquid 20%,Liposomal Glutathione Powder 70%
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Liposomal glutathione encapsulates glutathione in liposomes (a carrier), with the purpose of improving the body's absorption rate of glutathione and enhancing its stability. In a pilot clinical study, 12 healthy subjects were supplemented with 500 mg and 1 g of liposomal glutathione daily, and it was found that both doses of liposomal glutathione were effective. Absorbs and increases glutathione levels in the blood and cells, reducing oxidative stress in the body. After 2 weeks of supplementation, cell and plasma glutathione can be increased by 25% and 28% respectively, and the GSH/GSSG ratio can be increased by 20%.

Product Name

liposomal glutathione

Active Ingredients

glutathione

Specification

5%-20%liquid，50%-70%powder

Appearance

Yellow viscous liquid or light yellow powder

Inclusion compound excipients

Phospholipids

Desciption

Product information
What is liposomal glutathione
People usually supplement glutathione orally, but the problem is that as an antioxidant, glutathione is easily destroyed by gastric acid, so Joyous invented conjugated glutathione, liposomal glutathione. One of the types.
The main advantage of liposomal glutathione is improved absorption. There is a threshold in the ability of our intestinal cells to take up higher doses of glutathione. This is why taking higher doses of glutathione can cause excessive gas and/or diarrhea. The bioavailability of glutathione is significantly higher than that of regular glutathione, almost twice as much. Oral liposomal glutathione is often recommended as an alternative to intravenous (IV) glutathione.
Joyous liposomal glutathione specification

Terms	Standard	Terms	Standard
Product Name	liposomal glutathione	Appearance	Yellow viscous liquid or light yellow powder
Assay	5%-30%liquid，50%-70%powder	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

How are liposomal glutathione made?
When phospholipids are naturally dispersed in water, they form a closed bilayer structure with one end hydrophilic and the other lipophilic. Joyous liposome dosage forms are built around this property of phospholipids. First, we prepare the water phase and oil phase respectively, and then we can use three types of machines for nanoscale packaging processing, namely high-pressure homogenizer, nano-microjet and ultrasonic micro-jet. In the machine, Joyous products (such as glutathione) are gradually formed into uniform nanoparticles during shearing and collision, and then they are put into another machine for the extrusion process. This part allows us to control and screen the size of the nanoparticles, and after removing free parts (such as glutathione) in this process, the last step is of course the detection step. Observe the cross-section of liposome glutathione through an electron microscope to see whether it is consistent with our preset structure, and test the strength and dispersion to confirm whether its distribution is uniform. , and finally check the packaging rate. If the free part does not exceed 3%, that is, when the encapsulation rate reaches at least 97%, this part of the product is qualified. Of course, what we are introducing here is the production process of liquid liposomes.
Powder liposomes are divided into two situations during the production process. One is a crude liposome powder, produced in a simulated environment. We have introduced the characteristics of phospholipids before, and Joy Liposome is based on this characteristic. It comes from mixing phospholipids, water and the ingredients we need to package (such as glutathione) together, and repeatedly colliding and stirring them in an environment. . Constant temperature and pressure, and finally spray drying into powder, and add some medicinal anticoagulants. In this way, crude liposomes were obtained. This liposome is intended to be added to concepts and some low-end supplement products. It can play a certain liposome function, but obviously its function is not as strong as liquid, but the advantage is that the proportion of inclusion compounds is higher (the content can be high enough).
The second case is based on liquid liposomes, also subdivided into two modes. One is to freeze-dry the liposomes into powder in a low-temperature environment that does not destroy the activity of the product. The disadvantage is that when the liquid becomes powder, it will irreversibly transform from nanoparticle size to fine powder of 200 mesh to 120 mesh, which means that the penetration and absorption properties are lost. The advantage is that this is a complete liposome, which is more durable than crude liposome powder. Strong. Another case is what Joyous calls perfect liposome powder. It goes through some special processing. After turning into powder, if washed with water, it can be restored to nano-scale liposome glutathione liquid with lipid properties. It itself has almost all the functions of liposomes, but Joyous' technology has not yet made a breakthrough in this type of product, and only some large listed companies have launched it as a new drug product.
What are the benefits of liposomes？
As a new type of drug carrier, liposomes have the characteristics of protecting the encapsulated active ingredients from being degraded by the physiological environment, extending the half-life of the drug, controlling the release of drug molecules, and having good biocompatibility and safety. They can also pass through passive and/or active targets. It selectively delivers its encapsulated active ingredients to the diseased site, thereby reducing systemic side effects, increasing the maximum tolerated dose and improving therapeutic effects.
After consulting the relevant drug database and excluding generic drugs, lipoplexes and regionally approved products, a total of 14 liposome products have been approved for marketing worldwide.
Overview of liposome products
The first liposome product on the market was Doxil, a liposome injection of doxorubicin hydrochloride approved by the FDA in 1995. Among the liposome products on the market, 43% were approved before 2000 and 57% were approved before 2010. These liposome products are mainly focused on oncology treatment, but also cover other areas such as infection, anesthesia, vaccines, lung diseases and photodynamic therapy. The dosage forms of these liposome products are mainly sterile suspensions and lyophilized powders. Routes of administration include intravenous infusion, intramuscular and intrathecal injection, epidural administration, local infiltration, and oral inhalation. After the advent of COVID-19, vaccines based on liposome technology also shined.
Some other liposome products approved for marketing, such as malaria vaccine Mosquirix, hepatitis A vaccine Epaxal, influenza vaccine Inflexal, veterinary drug long-acting bupivacaine local anesthetic Nocita, etc. also have good sales.

According to the particle size of liposomes and the number of lipid bilayer membranes, liposomes can be divided into unilamellar liposomes (ULV); oligolamellar lipids (OLV, 100-1000nm); multilamellar liposomes Liposomes (Multilamellarvesicles, MLV, >500nm); Multivesicular liposomes (MVL, >1000nm).
There are four liposome products with particle sizes in the micron range, namely mivamut liposome Mepact, cytarabine liposome suspension DepoCyt, morphine sulfate sustained-release liposome injection DepoDur and bupivacaine Liposome Injectable Suspension Exparel. Mepact is a sterile freeze-dried cake that is reconstituted with 0.9% normal saline to form multilamellar liposomes with a particle size of 2.0~3.5μm. Particles of this size are conducive to recognition and phagocytosis by monocytes/macrophages, and Cancer therapy that triggers macrophage and immunomodulatory effects. DepoCyt, DepoDur and Exparel are produced using the same DepoFoam technology. Due to its many cavities in its structure, MVL can load a large amount of drug solution and achieve sustained release due to the slow erosion/degradation of liposomes and the slow diffusion of drug molecules. Electron microscopy images of Doxil, Vyxeos, DepoCyt and Mepact:

Current commercial products are designed to prolong circulation time, increase half-life, and passively target diseased sites, so most of them are SUVs. For example, the particle size of amikacin liposome inhalation suspension ARIKAYE is larger (200-300nm) and is considered LUV. Daunorubicin cytarabine liposome for injection Vyxeos is a bilayer liposome. This structure is formed during the first loading of cytarabine. The mechanism of internal thin layer formation is Interpreted as a thermodynamic response, the lipid bilayer decreases the surface area to volume ratio due to the penetration of the aqueous medium by external osmotic pressure.
Doxorubicin liposome Myocet and mivamut liposome Mepact are MLVs. A large number of lipid layers provide enough space for encapsulating lipophilic drugs.

Starting from the approval of the first liposome product Doxil in 1995, liposome technology has been developed for more than 20 years. By summarizing the successes and pain points based on numerous publications and commercial products, liposomes can be carefully designed and perform the desired function according to human needs. On the one hand, there are some major obstacles in the development and commercial production process, such as individual differences in the EPR effect, the effect of PEGylated liposomes, the phenomenon of accelerated blood clearance (ABC), process scale-up, different production batches and Site-to-site reproducibility/consistency, and excipient control. On the other hand, a large number of smart liposome systems are being developed in laboratories or undergoing clinical trials, such as active-targeting liposomes (anti-EGFR immunoliposomes, Phase II; MBP-426, Phase II) and sensitive liposomes. Plastids (ThermoDox). The microenvironment of the target lesion can be used to trigger liposomes to release drugs. External or internal stimuli (such as temperature, pH, light, electromagnetic fields, enzymes and hypoxia) are often studied as the "switch" (On-Off) of drug release. ). Although good results have been achieved in preclinical studies, successful clinical translation still faces challenges due to major issues such as vector leakage before reaching the target, individual patient differences, and the multimodal treatments involved. ThermoDox, the fastest-developing thermosensitive liposome, failed in the second phase of a Phase III clinical trial in combination with radiofrequency ablation for hepatocellular carcinoma. However, these failures only mean the failure of liposome products under certain clinical designs. Intelligent technology will provide many more opportunities for liposomes to further improve the efficacy and reduce side effects.
China's State Food and Drug Administration has approved five types of liposome products: paclitaxel liposomes, doxorubicin hydrochloride liposomes, amphotericin liposomes, mitoxantrone hydrochloride liposomes, and irinotecan hydrochloride liposomes Among them, paclitaxel liposomes and mitoxantrone liposomes are unique products in China.

There is little accurate market research data on liposomes. We made some comparisons based on search popularity and searched for literature related to liposomes from 1970 to 2020 on Scopus using liposomes as the keyword. Statistics of these results can be concluded: (1) Liposomes were used as drug carriers in fields such as food and cosmetics earlier than in nanomedicine (1970 vs. 1990); (2) Liposomes were used as drug carriers in liposomes Use in quality-related publications has increased over time, from 50% in 2000 to 70% in 2010 and to 74% in 2020;
(3) Although the development of nanomedicine lags behind the application of liposomes, the number of papers on nanomedicine has increased exponentially over time;
(4) The extremely low proportion of nanodrug liposomes in total nanodrugs (7%) may be due to incorrect data, because there were 3024 publications on liposomal drugs in 2020.
According to the FDA, as of February 18, 2016, more than 500 liposome applications had been received. Of these applications, 3% were NDAs, 1% were ANDAs, and 96% were INDs, except for approximately 100 submissions in which liposomes were used in combination with another therapeutic. Judging from the data collected in laboratories and the pharmaceutical industry, in the near future, there will be a large number of liposome products transformed from the laboratory to pilot production and finally launched on the market.

Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides liposomal glutathione OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy liposomal glutathione?
We offer the best liposomal glutathione at the most competitive price.liposomal glutathione bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide liposomal glutathione in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

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